Management of Pouchitis: Clinical Pearls for the Gastroenterologist

Authors

  • Neeraj Narula, MD, MPH, FRCPC Division of Gastroenterology, McMaster University

DOI:

https://doi.org/10.58931/cibdt.2023.116

Keywords:

pouchitis, inflammatory bowel disease

Abstract

Ileal pouch anal anastomosis (IPAA) is a surgical procedure conducted in patients with ulcerative colitis (UC) with medically refractory disease; in patients with the autosomal dominant inherited disease familial adenomatous polyposis (FAP); or in patients who have experienced dysplasia/colon cancer. The procedure aids in the management of these diseases, improves patients’ quality of life, prevents the need for a permanent stoma, and reduces the risk of colorectal cancer. A common complication from IPAA is pouchitis, which is characterized as an idiopathic non-specific inflammation within the created pouch resulting in symptoms including increased frequency of bowel movements and abdominal pain. Pouchitis is much more common in patients treated for UC (up to 60%) than in those receiving treatment for other indications (0-10%). This might be due to immune activation or dysbiosis in these patients.

Author Biography

Neeraj Narula, MD, MPH, FRCPC, Division of Gastroenterology, McMaster University

Neeraj Narula is currently an Associate Professor of Medicine at McMaster University and Staff Gastroenterologist at Hamilton Health Sciences, with a clinical and research focus in Inflammatory Bowel Diseases (IBD). He also serves as Director of the IBD clinic at Hamilton Health Sciences and Director of the IBD fellowship for McMaster University. During the course of his career, he has published over 120 peer-reviewed articles and 4 book chapters and he has received over $3 million in research funding and grants. His advanced training includes Present-Levison Advanced Inflammatory Bowel Diseases Fellowship at Mount Sinai Hospital (New York, NY) and Masters of Public Health at Harvard TH Chan School of Public Health (Boston, MA). He has been an invited speaker at several international congresses including Digestive Diseases Week (American Gastroenterology Association), European Crohn’s and Colitis Organization Conference, United European Gastroenterology Week, and Ontario Association of Gastroenterology Annual Meetings.

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Published

2023-04-11

How to Cite

1.
Narula N. Management of Pouchitis: Clinical Pearls for the Gastroenterologist. Can IBD Today [Internet]. 2023 Apr. 11 [cited 2024 Nov. 21];1(1):12–17. Available from: https://canadianibdtoday.com/article/view/1-1-2-narula

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Volume 1, Issue 1, April 2023

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