Colite ulcéreuse grave et aiguë : Examen de la prise en charge et des nouveaux traitements
Résumé
La colite ulcéreuse grave aiguë (CUGA) est une urgence médicale, accompagnée d’un taux de mortalité global de 1 %. Les patients atteints de colite ulcéreuse présentent un taux d’exacerbations graves de 20 à 25 % nécessitant une hospitalisation pour un traitement médical urgent, voire chirurgical. Le taux de nouvelle hospitalisation pour CUGA est de 34,4 % et celle-ci se produit généralement dans les 24 mois suivant la première admission. Le traitement requiert une approche multidisciplinaire centrée sur le patient qui comprend la gastro-entérologie, la chirurgie colorectale et le soutien nutritionnel afin de minimiser les complications de la maladie, les effets indésirables du traitement et les coûts des soins de santé.6 Les cliniciens et les patients disposent d’un nombre croissant d’options de traitement et doivent tenir compte de problèmes d’innocuité supplémentaires. Nous examinons l’approche actuelle de la prise en charge et résumons les nouvelles données sur l’utilisation de nouveaux agents pour traiter la CUGA.
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