Recent Advances in Complementary and Alternative Therapies for Inflammatory Bowel Disease
DOI:
https://doi.org/10.58931/cibdt.2024.2334Abstract
Inflammatory bowel disease (IBD) is a chronic relapsing-remitting inflammatory condition of the gastrointestinal (GI) tract, primarily comprised of 2 major types: Crohn's disease (CD) and ulcerative colitis (UC). The pathogenesis of IBD is not fully elucidated but is thought to be multifactorial involving genetic, environmental, and immunological contributors. The incidence of IBD has been rising worldwide, particularly in developed nations. Canada, in particular, has one of the highest prevalence rates of IBD globally, with recent data indicating that over 320,000 Canadians are living with IBD, making it a significant public health concern.
The chronic nature of IBD, along with the severity of its symptoms, and the adverse effects occasionally attributed to management (e.g. immunosuppression, corticosteroids, surgical complications) can significantly reduce the quality of life for those affected. As such, many patients with IBD use complementary and alternative medicine (CAM) due to safety concerns of conventional therapy and a sense of greater control over their disease. CAM refers to a broad range of healthcare practices, such as herbal medicine, acupuncture, homeopathy, fecal microbiota transplants, and probiotics, which are not typically considered part of conventional western medicine. The use of CAM among patients with IBD is high, with current or past use of CAM ranging from 21-60% of IBD patients. Given the propensity of patients with IBD to seek CAM and the unfamiliarity that many medical practitioners have with the evidence of benefit/harm from these practices, this review seeks to summarize recent advances in clinical research on CAM use for IBD.
References
Baumgart DC, Sandborn WJ. Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet Lond Engl. 2007;369(9573):1641–1657.
Kostic AD, Xavier RJ, Gevers D. The microbiome in inflammatory bowel disease: current status and the future ahead. Gastroenterology. 2014;146(6):1489–1499.
Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet Lond Engl. 2017;390(10114):2769–2778.
Coward S, Benchimol EI, Kuenzig ME, Windsor JW, Bernstein CN, Bitton A, et al. The 2023 impact of inflammatory bowel disease in Canada: epidemiology of IBD. J Can Assoc Gastroenterol. 2023;6(Suppl 2):S9–S15.
Knowles SR, Graff LA, Wilding H, Hewitt C, Keefer L, Mikocka-Walus A. Quality of life in inflammatory bowel disease: a systematic review and meta-analyses-part I. Inflamm Bowel Dis. 2018;24(4):742–751.
Langhorst J, Wulfert H, Lauche R, Klose P, Cramer H, Dobos GJ, et al. Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases. J Crohns Colitis. 2015;9(1):86–106.
Ernst E. The role of complementary and alternative medicine. BMJ. 2000;321(7269):1133–1135.
Zhou Y, Xu ZZ, He Y, Yang Y, Liu L, Lin Q, et al. Gut Microbiota offers universal biomarkers across ethnicity in inflammatory bowel disease diagnosis and infliximab response prediction. mSystems. 2018;3(1):e00188-17. doi:10.1128/mSystems.00188-17
Ni J, Wu GD, Albenberg L, Tomov VT. Gut microbiota and IBD: causation or correlation? Nat Rev Gastroenterol Hepatol. 2017;14(10):573–584.
Panaccione R, Steinhart AH, Bressler B, Khanna R, Marshall JK, Targownik L, et al. Canadian Association of Gastroenterology Clinical Practice Guideline for the Management of Luminal Crohn’s Disease. Clin Gastroenterol Hepatol. 2019;17(9):1680–1713.
Bressler B, Marshall JK, Bernstein CN, Bitton A, Jones J, Leontiadis GI, et al. Clinical Practice Guidelines for the medical management of nonhospitalized ulcerative colitis: the Toronto consensus. Gastroenterology. 2015;148(5):1035-1058.e3.
Lamb CA, Kennedy NA, Raine T, Hendy PA, Smith PJ, Limdi JK, et al. British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults. Gut. 2019;68(Suppl 3):s1–106.
Wang X, Zhou C, Zhang S, Ma Y, Xiao W, Guo Y. Additive efficacy and safety of probiotics in the treatment of ulcerative colitis: a systematic review and meta-analysis. Eur J Nutr. 2024;63(5):1395–1411.
Estevinho MM, Yuan Y, Rodríguez‐Lago I, Sousa‐Pimenta M, Dias CC, Barreiro‐de Acosta M, et al. Efficacy and safety of probiotics in IBD: An overview of systematic reviews and updated meta‐analysis of randomized controlled trials. United Eur Gastroenterol J. 2024;12(7):960–981.
Alphonsus L, De Silva TA, Ma C, MacDonald JK, Hanzel J, Beaton M, et al. Systematic review and meta-analysis of randomised controlled trials: medical therapies for the treatment and prevention of pouchitis. Aliment Pharmacol Ther. 2023;58(3):268–282.
Borody TJ, Khoruts A. Fecal microbiota transplantation and emerging applications. Nat Rev Gastroenterol Hepatol. 2011;9(2):88–96.
Moayyedi P, Surette MG, Kim PT, Libertucci J, Wolfe M, Onischi C, et al. Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial. Gastroenterology. 2015;149(1):102-109.e6.
Tan XY, Xie YJ, Liu XL, Li XY, Jia B. A systematic review and meta-analysis of randomized controlled trials of fecal microbiota transplantation for the treatment of inflammatory bowel disease. Evid-Based Complement Altern Med. 2022;2022:8266793. doi:10.1155/2022/8266793
Ambrose T, Simmons A. Cannabis, cannabinoids, and the endocannabinoid system—is there therapeutic potential for inflammatory bowel disease? J Crohns Colitis. 2019;13(4):525–535.
Doeve BH, Van De Meeberg MM, Van Schaik FDM, Fidder HH. A systematic review with meta-analysis of the efficacy of cannabis and cannabinoids for inflammatory bowel disease: what can we learn from randomized and nonrandomized studies? J Clin Gastroenterol. 2021;55(9):798–809.
Ajabnoor SM, Thorpe G, Abdelhamid A, Hooper L. Long-term effects of increasing omega-3, omega-6 and total polyunsaturated fats on inflammatory bowel disease and markers of inflammation: a systematic review and meta-analysis of randomized controlled trials. Eur J Nutr. 2021;60(5):2293–2316.
Feagan BG, Sandborn WJ, Mittmann U, Bar-Meir S, D’Haens G, Bradette M, et al. Omega-3 free fatty acids for the maintenance of remission in Crohn disease: the EPIC randomized controlled trials. JAMA. 2008;299(14):1690–1697.
Hanai H, Sugimoto K. Curcumin has Bright Prospects for the Treatment of Inflammatory Bowel Disease. Curr Pharm Des. 2009 Jun 1;15(18):2087–94.
Vecchi Brumatti L, Marcuzzi A, Tricarico P, Zanin V, Girardelli M, Bianco A. Curcumin and Inflammatory Bowel Disease: Potential and Limits of Innovative Treatments. Molecules. 2014 Dec 16;19(12):21127–53.
Suzuki H, Kaneko T, Mizokami Y, Narasaka T, Endo S, Matsui H, et al. Therapeutic efficacy of the Qing Dai in patients with intractable ulcerative colitis. World J Gastroenterol. 2013 May 7;19(17):2718–22.
Naganuma M, Sugimoto S, Mitsuyama K, Kobayashi T, Yoshimura N, Ohi H, et al. Efficacy of Indigo Naturalis in a Multicenter Randomized Controlled Trial of Patients With Ulcerative Colitis. Gastroenterology. 2018 Mar;154(4):935–47.
Saiki JP, Andreasson JO, Grimes KV, Frumkin LR, Sanjines E, Davidson MG, et al. Treatment-refractory ulcerative colitis responsive to indigo naturalis. BMJ Open Gastroenterol. 2021 Dec;8(1):e000813
Ben-Horin S, Salomon N, Karampekos G, Viazis N, Lahat A, Ungar B, et al. Curcumin-QingDai Combination for Patients With Active Ulcerative Colitis: A Randomized, Double-Blinded, Placebo-Controlled Trial. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc. 2024 Feb;22(2):347-356.e6.
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Canadian IBD Today
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.