A Review of Pediatric to Adult Transition of Care in Inflammatory Bowel Disease
DOI:
https://doi.org/10.58931/cibdt.2024.2337Abstract
Canada is reported to have one of the highest rates of both incidence and prevalence of inflammatory bowel disease (IBD). Benchimol et al. conducted a population-based cohort study from 1999-2008 using health administrative data from Ontario, Canada, and reported that the prevalence of IBD in Canada in 2008 was 534.3 per 100,000 people (68,017 affected individuals among 12,738,350 Ontario residents). Between 1999 and 2008, the incidence of IBD increased annually in children under the age of 10 (9.7% per year, p<0.0001) and in those aged 10-19 (3.8% per year, p<0.0001).
Coward et al. published a similar population based health administrative data study using data from eight provinces in Canada. In this study the national incidence of IBD was estimated to be 29.9 per 100,000 (95% PI 28.3-31.5) in 2023.ll The incidence of IBD in pediatric patients was found to be increasing (average annual percentage change (AAPC) 1.27%; 95% CI 0.82-1.67). The prevalence of IBD was 843 per 100,000 (95% PI 716-735) in 2023 with forecasted increases (AAPC 2.43%;95% CI 2.32-2.54). In pediatric patients the prevalence in 2023 was 82 (95% PI 77-88) and the forecasted AAPC was 1.91 (1.46-2.31).
According to the 2023 Impact of IBD in Canada Report by Crohn’s and Colitis Canada, an estimated 322,600 Canadians are living with IBD, with 11,000 new diagnoses expected in 2023.
The global incidence and prevalence of IBD has been rising. In 2011, Benchimol et al. published a systematic review detailing international trends in IBD. The review demonstrated a 60% increase in Crohn’s disease (CD) and a 20% increase in ulcerative colitis (UC) across both developing and developed countries. Benchimol et al. also published the results of a health administrative data analysis evaluating children with a diagnosis of IBD between 1999-2010 across five Canadian provinces, which together account for 79.2% of the Canadian population. They reported that incidence of IBD in children aged five and under increased during the study period (annual percentage increase [APC] +7.19%; 95% CI, +2.82% to +11.56%). The prevalence of IBD also increased significantly during the study period (APC+4.56%; 95% CI, +3.71%
to +5.42%).
References
Benchimol EI, Manuel DG, Guttmann A, Nguyen GC, Mojaverian N, Quach P, et al. Changing age demographics of inflammatory bowel disease in Ontario, Canada: a population-based cohort study of epidemiology trends. Inflamm Bowel Dis. 2014;20(10):1761-1769. doi:10.1097/mib.0000000000000103
Coward S, Benchimol EI, Bernstein CN, Avina-Zubieta A, Bitton A, Carroll MW, et al. Forecasting the incidence and prevalence of inflammatory bowel disease: a Canadian nationwide analysis. Am J Gastroenterol. 2024 Aug 1;119(8):1563-1570. doi: 10.14309/ajg.0000000000002687
Kuenzig ME, Fung SG, Marderfeld L, Mak JWY, Kaplan GG, Ng SC, et al. Twenty-first century trends in the global epidemiology of pediatric-onset inflammatory bowel disease: systematic review. Gastroenterology. 2022 Apr;162(4):1147-1159.e4. doi: 10.1053/j.gastro.2021.12.282
Windsor JW, Kuenzig ME, Murthy SK, Bitton A, Bernstein CN, Jones JL, et al. The 2023 impact of inflammatory bowel disease in Canada: executive summary. J Can Assoc Gastroenterol. 2023 Jun 1;6(Suppl 2):S1-S8. doi: 10.1093/jcag/gwad003. Erratum in: J Can Assoc Gastroenterol. 2023 Nov 13;6(6):255. doi: 10.1093/jcag/gwad038
El-Matary W, Carroll MW, Deslandres C, Griffiths AM, Kuenzig ME, Mack DR, et al. The 2023 impact of inflammatory bowel disease in Canada: special populations-children and adolescents with IBD. J Can Assoc Gastroenterol. 2023 Sep 5;6(Suppl 2):S35-S44. doi: 10.1093/jcag/gwad016
Benchimol EI, Fortinsky KJ, Gozdyra P, Van den Heuvel M, Van Limbergen J, Griffiths AM. Epidemiology of pediatric inflammatory bowel disease: a systematic review of international trends. Inflamm Bowel Dis. 2011;17(1):423-439. doi:10.1002/ibd.21349
Benchimol EI, Bernstein CN, Bitton A, Carroll MW, Singh H, Otley AR, et al. Trends in epidemiology of pediatric inflammatory bowel disease in Canada: distributed network analysis of multiple population-based Provincial health administrative databases. Am J Gastroenterol. 2017;112(7):1120-1134. doi:10.1038/ajg.2017.97
Kaplan GG, Windsor JW. The four epidemiological stages in the global evolution of inflammatory bowel disease. Nat Rev Gastroenterol Hepatol. 2021 Jan;18(1):56-66. doi: 10.1038/s41575-020-00360-x
Blum RW, Garell D, Hodgman CH, Jorissen TW, Okinow NA, Orr DP, et al. Transition from child-centered to adult health-care systems for adolescents with chronic conditions. A position paper of the Society for Adolescent Medicine. J Adolesc Health. 1993;14(7):570-576. doi:10.1016/1054-139x(93)90143-d
Child and Adolescent Health Measurement Initiative. 2021-2022 National Survey of Children's Health (NSCH) data query. Data Resource Center for Child and Adolescent Health, supported by the U.S. Department of Health and Human Services, Health Resources and Services Administration (HRSA), Maternal and Child Health Bureau (MCHB); 2022. Available from: https://www.childhealthdata.org/browse/survey/results?q=10623&r=1.
Jawaid N, Jeyalingam T, Nguyen G, Bollegala N. Paediatric to adult transition of care in IBD: understanding the current standard of care among Canadian adult academic gastroenterologists. J Can Assoc Gastroenterol. 2020;3(6):266-273. doi:10.1093/jcag/gwz023
Bihari A, Hamidi N, Seow CH, Goodman KJ, Wine E, Kroeker KI. Defining transition success for young adults with inflammatory bowel disease according to patients, parents and health care providers. J Can Assoc Gastroenterol. 2022;5(4):192-198. doi:10.1093/jcag/gwac004 Johnson LE, Lee MJ, Turner-Moore R, Grinsted Tate LR, Brooks AJ, Tattersall RS, et al. Systematic review of factors affecting transition readiness skills in patients with inflammatory bowel disease. J Crohns Colitis. 2021;15(6):1049-1059. doi:10.1093/ecco-jcc/jjaa245
Bottema RWB, de Vries H, Houwen RHJ, van Rheenen PF. Impact of paediatric versus adult care setting on health care utilization in adolescents with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2019;69(3):310-316. doi:10.1097/mpg.0000000000002399
Zhao X, Bjerre LM, Nguyen GC, Mack DR, Manuel DG, Hawken S, et al. Health services use during transition from pediatric to adult care for inflammatory bowel disease: a population-based study using health administrative data. J Pediatr. 2018;203:280-287.e284. doi:10.1016/j.jpeds.2018.08.021
Bollegala N, Barwick M, Fu N, Griffiths AM, Keefer L, Kohut SA, Kroeker KI, Lawrence S, Lee K, Mack DR, Walters TD, de Guzman J, Tersigni C, Miatello A, Benchimol EI. Multimodal intervention to improve the transition of patients with inflammatory bowel disease from pediatric to adult care: protocol for a randomized controlled trial. BMC Gastroenterol. 2022 May 18;22(1):251. doi: 10.1186/s12876-022-02307-9.
Erős A, Soós A, Hegyi P, Szakács Z, Erőss B, Párniczky A, et al. Spotlight on transition in patients with inflammatory bowel disease: a systematic review. Inflamm Bowel Dis. 2020;26(3):331-346. doi:10.1093/ibd/izz173
Corsello A, Pugliese D, Bracci F, Knafelz D, Papadatou B, Aloi M, et al. Transition of inflammatory bowel disease patients from pediatric to adult care: an observational study on a joint-visits approach. Ital J Pediatr. 2021;47(1):18. doi:10.1186/s13052-021-00977-x
Marani H, Fujioka J, Tabatabavakili S, Bollegala N. Systematic narrative review of pediatric-to-adult care transition models for youth with pediatric-onset chronic conditions. Children and Youth Services Review. 2020;118:105415. doi:https://doi.org/10.1016/j.childyouth.2020.105415
Vernon-Roberts A, Chan P, Christensen B, Havrlant R, Giles E, Williams AJ. Pediatric to adult transition in inflammatory bowel disease: consensus guidelines for Australia and New Zealand. Inflamm Bowel Dis. 2024. doi:10.1093/ibd/izae087
Brooks AJ, Smith PJ, Cohen R, Collins P, Douds A, Forbes V, et al. UK guideline on transition of adolescent and young persons with chronic digestive diseases from paediatric to adult care. Gut. 2017;66(6):988-1000. doi:10.1136/gutjnl-2016-313000
Fu N, Bollegala N, Jacobson K, Kroeker KI, Frost K, Afif W, et al. Canadian consensus statements on the transition of adolescents and young adults with inflammatory bowel disease from pediatric to adult care: a collaborative initiative between the Canadian IBD Transition Network and Crohn's and Colitis Canada. J Can Assoc Gastroenterol. 2022;5(3):105-115. doi:10.1093/jcag/gwab050
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Canadian IBD Today
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.